Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28903530 | 0.78 | ALDH1A1 (0.48) | TDP1ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL28327449 | 0.77 | ALDH1A1 (0.46) | TDP1ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL7028200 | 0.77 | ALDH1A1 (0.46) | TDP1ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL11539058 | 0.77 | TDP1 (0.49) | TDP1PDE10AALDH1A1KDM4EMAPT | |
| SCHEMBL12672178 | 0.77 | ALDH1A1 (0.35) | PDE10AALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL6602161 | 0.74 | KDM4E (0.70) | TDP1PDE10AALDH1A1KDM4EMAPT | |
| SCHEMBL22134947 | 0.74 | KDM1A (0.49) | TDP1PDE10AALDH1A1KDM4EMAPT | |
| SCHEMBL19321566 | 0.74 | MAPT (0.63) | TDP1ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL5745605 | 0.74 | TDP1 (0.59) | TDP1PDE10AALDH1A1KDM4EMAPT | |
| SCHEMBL30395230 | 0.74 | TDP1 (0.59) | TDP1PDE10AALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254623-B1 | AMINOALKYLTHIO TRIAZOLOPYRIDINE OR TRIAZOLOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, PARTICULARLY USEFUL AS ANTALGICS | LABORATOIRES UPSA (FR) | 1993-06-09 | — | — | EP | disclosed |
| US-4886805-A | Novel aminoalkylthio derivatives of triazolopyridine or triazoloquinoline, the processes for their preparation, and drugs, useful especially as analgesics, in which they are present | Centre D'Activite Et De Recherches Pharmaceutique Industrielle Biologique Medicale (FR) | 1989-12-12 | — | — | US | disclosed |
| EP-0254623-A1 | Aminoalkylthio triazolopyridine or triazoloquinoline derivatives, process for their preparation, medicaments containing them, particularly useful as antalgics | LABORATOIRES UPSA (FR) | 1988-01-27 | — | — | EP | disclosed |