Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 18/20 | 0.74 |
| ▸ | GABRG2 | P18507 | 18/20 | 0.74 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.74 |
| ▸ | GABRA5 | P31644 | 18/20 | 0.74 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.74 |
| ▸ | GABRA2 | P47869 | 16/20 | 0.74 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.74 |
| ▸ | GABRP | O00591 | 7/20 | 0.74 |
| ▸ | GABRD | O14764 | 7/20 | 0.74 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.74 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.74 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.74 |
| ▸ | GABRE | P78334 | 7/20 | 0.74 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.74 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.74 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389622 | 0.92 | GABRA1 (0.69) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10417347 | 0.92 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10708316 | 0.91 | GABRA1 (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10389289 | 0.90 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10389611 | 0.90 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9535806 | 0.89 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10389643 | 0.89 | GABRA1 (0.89) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10389614 | 0.88 | GABRA1 (0.72) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10390449 | 0.88 | GABRA1 (0.80) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9535854 | 0.88 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234173-B1 | PHENOXY-SUBSTITUTED BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | claimed |
| US-4945090-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-07-31 | — | — | US | claimed |
| US-4945090-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-07-31 | — | — | US | disclosed |