Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301520 | 0.85 | ALOX5 (0.61) | ALOX5PTGS1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL9302806 | 0.85 | ALOX5 (0.61) | ALOX5PTGS1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL24067376 | 0.75 | CYP11B1 (0.51) | ALOX5PTGS1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL25670602 | 0.72 | NPC1 (0.50) | ALOX5PTGS1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL9539358 | 0.71 | CYP3A4 (0.48) | MAPTSMN1; SMN2RAB9ANPC1CYP2A6 | |
| SCHEMBL25670604 | 0.71 | ALOX5 (0.45) | ALOX5PTGS1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL29691639 | 0.70 | CYP11B1 (0.86) | ALOX5PTGS1PTGS2MAPTCYP11B1 | |
| SCHEMBL6868428 | 0.70 | PTGS1 (1.00) | ALOX5PTGS1PTGS2MAPTCYP11B1 | |
| SCHEMBL29691623 | 0.70 | CYP11B1 (0.86) | ALOX5PTGS1PTGS2MAPTCYP11B1 | |
| SCHEMBL10534390 | 0.70 | PTGS1 (1.00) | ALOX5PTGS1PTGS2MAPTCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569491-A4 | 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | — | 1993-11-24 | — | — | EP | claimed |