Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535886 | 0.92 | KCNH2 (0.59) | KCNH2NR4A2GRIN1GRIN2BSOS1 | |
| SCHEMBL9540203 | 0.87 | KCNH2 (0.64) | KCNH2NR4A2SOS1HTR3ACHRM1 | |
| SCHEMBL9538624 | 0.84 | KCNH2 (0.63) | KCNH2NR4A2SOS1HTR3ACHRM1 | |
| SCHEMBL9382803 | 0.84 | KCNH2 (0.64) | KCNH2NR4A2HTR3ACHRM1HRH1 | |
| Hydrochloric Acid SCHEMBL9539127 | 0.83 | KCNH2 (0.56) | KCNH2NR4A2SOS1TBXA2RHTR3A | |
| Bromide SCHEMBL10550754 | 0.81 | KCNH2 (0.55) | KCNH2NR4A2GRIN1GRIN2BTBXA2R | |
| SCHEMBL9535904 | 0.80 | KCNH2 (0.54) | KCNH2NR4A2HTR3ACHRM1HRH1 | |
| SCHEMBL10548476 | 0.79 | KCNH2 (0.62) | KCNH2NR4A2SOS1 | |
| SCHEMBL10551636 | 0.79 | KCNH2 (0.62) | KCNH2NR4A2SOS1 | |
| Fumaric Acid SCHEMBL10818415 | 0.79 | KCNH2 (0.55) | KCNH2NR4A2HTR3ACHRM1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |