Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10553663 | 0.92 | ENPP2 (0.48) | KCNH2ENPP2NR4A2HPGDTP53 | |
| SCHEMBL9538624 | 0.85 | KCNH2 (0.63) | KCNH2NR4A2HTR3ARAB9ACHRM1 | |
| SCHEMBL9382803 | 0.85 | KCNH2 (0.64) | KCNH2NR4A2HTR3ARAB9ACHRM1 | |
| SCHEMBL9538842 | 0.83 | SSTR5 (0.52) | ENPP2RAB9A | |
| SCHEMBL9537733 | 0.83 | ENPP2 (0.44) | ENPP2HPGDTP53MAPTLMNA | |
| SCHEMBL9535886 | 0.82 | KCNH2 (0.59) | KCNH2NR4A2HTR3ARAB9ACHRM1 | |
| SCHEMBL9565088 | 0.82 | KCNH2 (0.48) | KCNH2NR4A2HPGDLMNAHTR3A | |
| SCHEMBL9564851 | 0.80 | CYP1A2 (0.54) | KCNH2NR4A2HPGDLMNASMN1; SMN2 | |
| SCHEMBL9537437 | 0.80 | KCNH2 (0.59) | KCNH2NR4A2HTR3ACHRM1HRH1 | |
| SCHEMBL9540203 | 0.80 | KCNH2 (0.64) | KCNH2NR4A2HTR3ARAB9ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |