Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 19/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21465564 | 0.92 | MAPK8 (0.47) | MAPK8MAPK9KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8117298 | 0.88 | MAPK8 (0.49) | MAPK8MAPK9KDM4EMAPT | |
| SCHEMBL9539511 | 0.85 | KDM4E (0.58) | MAPK8KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9537285 | 0.84 | MAPK8 (0.56) | MAPK8MAPK9KDM4ECYP1A2CYP3A4 | |
| SCHEMBL27291037 | 0.83 | MAPK8 (0.55) | MAPK8MAPK9 | |
| SCHEMBL9538268 | 0.82 | MAPK8 (0.52) | MAPK8MAPK9KDM4ECYP1A2CYP3A4 | |
| SCHEMBL21465642 | 0.80 | PPARG (0.56) | MAPK8MAPK9 | |
| SCHEMBL21465656 | 0.78 | MAPK8 (0.47) | MAPK8MAPK9KDM4EMAPTPKM | |
| SCHEMBL15005391 | 0.77 | ALDH1A1 (0.70) | MAPK8KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12983220 | 0.77 | MAPK8 (0.74) | MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| CN-1005974-B | Process for preparing acid indole compounds | 沃纳·兰伯特公司 | 1989-12-06 | — | — | CN | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |