Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978283 | 0.82 | FFAR1 (0.57) | LMNAFFAR1 | |
| SCHEMBL3983563 | 0.82 | PARP10 (0.51) | PARP10HDAC6 | |
| SCHEMBL221207 | 0.81 | MAOB (0.48) | PARP10ALOX5NR4A1NR4A2NR4A3 | |
| SCHEMBL9375612 | 0.79 | NOX1 (0.59) | PARP10ALOX5NR4A1NR4A2NR4A3 | |
| SCHEMBL4991366 | 0.79 | HDAC1 (0.50) | PARP10ALOX5HDAC6RAB9AFFAR1 | |
| SCHEMBL653551 | 0.79 | PARP10 (0.55) | PARP10ALOX5MAOASMN1; SMN2SRD5A2 | |
| SCHEMBL8331017 | 0.78 | LMNA (0.56) | PARP10ALOX5NR4A1NR4A2NR4A3 | |
| SCHEMBL10548607 | 0.78 | PARP10 (0.56) | PARP10LMNACYP1A2MAOBMAPT | |
| SCHEMBL4364701 | 0.77 | KMT2A (0.51) | NR4A1NR4A2NR4A3CYP1A2NOX1 | |
| SCHEMBL6711589 | 0.76 | TAAR1 (0.44) | PARP10CYP1A2SMN1; SMN2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536151-A1 | ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM. | BOOTS CO PLC (GB) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000273-A1 | ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | THE BOOTS COMPANY PLC (GB) | 1992-01-09 | — | — | WO | disclosed |