Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | HTR3A | P46098 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EED | O75530 | 2/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.49 |
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537805 | 0.93 | SSTR5 (0.56) | SSTR5HTR1AHTR3AHTTEED | |
| SCHEMBL9536730 | 0.88 | SSTR5 (0.52) | SSTR5HTR1AHTR3AHTR3EHTR3B | |
| SCHEMBL9537835 | 0.86 | SSTR5 (0.59) | SSTR5HTTALDH1A1TBXA2RHRH1 | |
| SCHEMBL10547393 | 0.85 | KCNH2 (0.46) | SSTR5MEN1DRD2DRD4KMT2A | |
| SCHEMBL9536543 | 0.85 | SSTR5 (0.66) | SSTR5ALDH1A1HRH1MEN1ABCB11 | |
| Oxalic Acid SCHEMBL10549021 | 0.84 | KMT2A (0.53) | ALDH1A1POLBMEN1LMNADRD2 | |
| Oxalic Acid SCHEMBL10549014 | 0.84 | KMT2A (0.53) | ALDH1A1POLBMEN1LMNADRD2 | |
| Hydrochloric Acid SCHEMBL9539127 | 0.83 | KCNH2 (0.56) | SSTR5HTR1AHTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL9537185 | 0.83 | HTR1A (0.57) | SSTR5HTR1AHTR3AHTTEED | |
| SCHEMBL9540175 | 0.83 | KCNH2 (0.71) | SSTR5HTR1AHTR3AHTTEED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |