Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9539127 | 0.90 | KCNH2 (0.56) | KCNH2NR4A2SSTR5SOS1HTR3A | |
| SCHEMBL9538624 | 0.88 | KCNH2 (0.63) | KCNH2NR4A2SOS1HTR3ARAB9A | |
| SCHEMBL9537805 | 0.85 | SSTR5 (0.56) | KCNH2SSTR5HTR3ATBXA2R | |
| SCHEMBL9535886 | 0.85 | KCNH2 (0.59) | KCNH2NR4A2SOS1HTR3ARAB9A | |
| SCHEMBL10548476 | 0.84 | KCNH2 (0.62) | KCNH2NR4A2SOS1RAB9A | |
| SCHEMBL10551636 | 0.84 | KCNH2 (0.62) | KCNH2NR4A2SOS1RAB9A | |
| SCHEMBL9537539 | 0.83 | HTR3A (0.62) | KCNH2HTR3ATBXA2R | |
| Oxalic Acid SCHEMBL10549909 | 0.82 | KCNH2 (0.56) | KCNH2NR4A2SOS1TBXA2R | |
| Oxalic Acid SCHEMBL10549899 | 0.82 | KCNH2 (0.56) | KCNH2NR4A2SOS1TBXA2R | |
| SCHEMBL9382803 | 0.82 | KCNH2 (0.64) | KCNH2NR4A2HTR3ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |