Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | MIF | P14174 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 2/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535419 | 0.90 | POLB (0.69) | MAPTHTR6POLBALDH1A1GAA | |
| SCHEMBL22456085 | 0.84 | MAPT (0.64) | MAPTHTR6POLBALDH1A1GAA | |
| SCHEMBL22455977 | 0.81 | MAPT (0.61) | MAPTHTR6POLBALDH1A1GAA | |
| SCHEMBL22455911 | 0.81 | MAPT (0.60) | MAPTHTR6POLBALDH1A1GAA | |
| SCHEMBL6474847 | 0.80 | HTR6 (0.58) | MAPTHTR6POLBALDH1A1GAA | |
| SCHEMBL4309629 | 0.79 | MAPT (0.62) | MAPTPOLBALDH1A1CRHBPCRHR2 | |
| SCHEMBL9698164 | 0.79 | MAPT (0.63) | MAPTHTR6POLBALDH1A1GAA | |
| SCHEMBL22440865 | 0.78 | CA12 (0.60) | MAPTHTR6POLBALDH1A1GAA | |
| SCHEMBL2013684 | 0.77 | SMN1; SMN2 (0.60) | MAPTHTR6ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL23144814 | 0.77 | MAPT (0.60) | MAPTPOLBALDH1A1GAACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |