Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FNIP1 | Q8TF40 | 1/20 | 0.41 |
| ▸ | FEM1B | Q9UK73 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078031 | 0.92 | PTGDR2 (0.60) | PTGDR2CYP2C8CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL950511 | 0.85 | PTGDR2 (0.60) | PTGDR2CYP2C8CYP2C9CYP2C19TRPM8 | |
| SCHEMBL950694 | 0.82 | PTGDR2 (0.63) | PTGDR2CYP2C8CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL950410 | 0.81 | PTGDR2 (0.64) | PTGDR2CYP2C8CYP2C9CYP2C19LTB4R2 | |
| SCHEMBL955843 | 0.77 | PTGDR2 (0.64) | PTGDR2CYP2C8CYP2C9CYP2C19RAB9A | |
| SCHEMBL2680756 | 0.76 | PTGDR2 (0.72) | PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL14229160 | 0.74 | TP53 (0.52) | ALDH1A1NPC1RAB9ASMN1; SMN2LTB4R2 | |
| SCHEMBL950049 | 0.73 | PTGDR2 (0.61) | PTGDR2CYP2C8CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL933416 | 0.73 | LTB4R2 (0.47) | PTGDR2LTB4R2 | |
| SCHEMBL934341 | 0.73 | LTB4R2 (0.64) | PTGDR2CYP2C8CYP2C9CYP2C19LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454243-A2 | TETRAZOLE DERIVATIVES | Merck Serono SA (CH) | 2012-05-23 | — | — | EP | disclosed |
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | TSLP, IL5, CMA1 | PTGDR2 548/4885CYP2C8 108/4885CYP2C9 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.