Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537742 | 0.84 | PSEN1 (0.47) | HSP90AA1L3MBTL1ALDH1A1KDM4EPSEN1 | |
| SCHEMBL9538881 | 0.83 | ADORA3 (0.44) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL9536261 | 0.83 | HSP90AA1 (0.45) | HSP90AA1ALDH1A1KDM4ENPSR1PSEN1 | |
| SCHEMBL9538217 | 0.82 | CYP11B1 (0.39) | HSP90AA1ALDH1A1KDM4EHPGDPSEN1 | |
| SCHEMBL9537162 | 0.81 | ADORA3 (0.44) | HSP90AA1ALDH1A1RECQLNPSR1MEN1 | |
| SCHEMBL9537326 | 0.79 | PSEN1 (0.48) | ROCK1POLBALDH1A1KDM4EHPGD | |
| SCHEMBL9537585 | 0.78 | KMT2A (0.39) | POLBL3MBTL1ALDH1A1KDM4EPSEN1 | |
| SCHEMBL9537661 | 0.78 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1KDM4EPSEN1PSEN2 | |
| SCHEMBL9536514 | 0.77 | MAPT (0.40) | POLBL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL9538041 | 0.76 | PSEN1 (0.44) | HSP90AA1ALDH1A1KDM4ENPSR1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |