Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477010 | 0.75 | TSHR (0.66) | MEN1KMT2AHPGDTSHRMAPK1 | |
| SCHEMBL4740278 | 0.68 | MAPK1 (0.58) | HPGDTSHRMAPK1USP2ALDH1A1 | |
| SCHEMBL30195348 | 0.67 | MAPK1 (0.66) | HPGDTSHRMAPK1USP2ALDH1A1 | |
| SCHEMBL20783160 | 0.67 | MAPK1 (0.66) | MEN1KMT2AHPGDTSHRMAPK1 | |
| SCHEMBL14198763 | 0.67 | MAPK1 (0.70) | HPGDTSHRMAPK1USP2ALDH1A1 | |
| SCHEMBL5162639 | 0.63 | ALDH1A1 (0.68) | HPGDTSHRMAPK1USP2ALDH1A1 | |
| SCHEMBL2600306 | 0.62 | MAPK1 (0.52) | MEN1KMT2AHPGDTSHRMAPK1 | |
| SCHEMBL29591678 | 0.62 | MAPK1 (0.52) | MEN1KMT2AHPGDTSHRMAPK1 | |
| SCHEMBL10915913 | 0.62 | MAPK1 (0.72) | MEN1KMT2AHPGDTSHRMAPK1 | |
| SCHEMBL3049673 | 0.62 | MAPK1 (0.72) | HPGDTSHRMAPK1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555251-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007838-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | disclosed |