Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.38 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.54 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.54 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.54 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.54 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.54 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.54 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.54 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.54 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4622023 | 1.00 | DRD2 (0.55) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| Bromide SCHEMBL29661592 | 1.00 | DRD2 (0.55) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| SCHEMBL93915 | 0.98 | DRD2 (0.57) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| SCHEMBL29358285 | 0.98 | DRD2 (0.57) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| Hydrochloric Acid SCHEMBL7571627 | 0.95 | DRD2 (0.55) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| SCHEMBL7572217 | 0.88 | DRD2 (0.48) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| SCHEMBL9015344 | 0.85 | DRD2 (0.65) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| SCHEMBL20877573 | 0.84 | KDM4E (0.49) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| SCHEMBL8652483 | 0.81 | DRD2 (0.55) | DRD2DRD4ADCY6ADCY3ADCY9 | |
| SCHEMBL8644945 | 0.81 | DRD2 (0.50) | DRD2DRD4ADCY6ADCY3ADCY9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530229-A1 | OXIDATION COLORANTS FOR KERATIN FIBRES. | HENKEL KGAA (DE) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991017739-A1 | OXIDATION COLORANTS FOR KERATIN FIBRES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1991-11-28 | — | — | WO | disclosed |