Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 12/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20703984 | 0.89 | NPC1 (0.66) | TXNRD1NPC1HTTPRKCQMAPT | |
| SCHEMBL29599605 | 0.89 | NPC1 (0.66) | TXNRD1NPC1HTTPRKCQMAPT | |
| SCHEMBL1329762 | 0.81 | MAPT (0.58) | TXNRD1NPC1HTTPRKCQHTR6 | |
| SCHEMBL28489675 | 0.80 | TXNRD1 (0.57) | TXNRD1HTTMAPT | |
| SCHEMBL4938289 | 0.78 | NPC1 (0.61) | TXNRD1NPC1HTTPRKCQMAPT | |
| SCHEMBL10654754 | 0.78 | TXNRD1 (0.55) | TXNRD1HTTMAPTL3MBTL1 | |
| SCHEMBL30858939 | 0.78 | NPC1 (0.65) | TXNRD1NPC1HTTPRKCQMAPT | |
| SCHEMBL3722434 | 0.78 | NPC1 (0.65) | TXNRD1NPC1HTTPRKCQMAPT | |
| SCHEMBL7850157 | 0.78 | BDKRB1 (0.51) | NPC1MAPT | |
| SCHEMBL9538090 | 0.77 | TXNRD1 (0.60) | TXNRD1NPC1HTR6MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |