Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 0.47 |
| ▸ | BCHE | P06276 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541130 | 0.99 | ACHE (0.47) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL2463186 | 0.99 | ACHE (0.47) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL2463181 | 0.99 | ACHE (0.47) | ACHEBCHEKDM4ECYP2D6TP53 | |
| Fumaric Acid SCHEMBL9538218 | 0.89 | KDM4E (0.54) | ACHEBCHEKDM4ECYP2D6CYP1A2 | |
| Fumaric Acid SCHEMBL9538223 | 0.89 | KDM4E (0.54) | ACHEBCHEKDM4ECYP2D6CYP1A2 | |
| SCHEMBL9207689 | 0.85 | ACHE (0.51) | ACHEBCHEKDM4ECYP2D6CYP1A2 | |
| Bromide SCHEMBL9538514 | 0.85 | ACHE (0.37) | ACHEBCHE | |
| SCHEMBL2456922 | 0.84 | ACHE (0.47) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL2456919 | 0.84 | ACHE (0.47) | ACHEBCHEKDM4ECYP2D6TP53 | |
| Bromide SCHEMBL9539133 | 0.84 | ACHE (0.37) | ACHEBCHEOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187165-A | Eseroline derivatives; cholinergic agents; antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-02-16 | — | — | US | disclosed |