Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 19/20 | 0.70 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951429 | 0.88 | PTGDR2 (0.61) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL950666 | 0.88 | PTGDR2 (0.67) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL952224 | 0.87 | PTGDR2 (0.68) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL953711 | 0.87 | PTGDR2 (0.71) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL954237 | 0.86 | PTGDR2 (0.56) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL955571 | 0.85 | PTGDR2 (0.69) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL950944 | 0.84 | PTGDR2 (0.70) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL12944493 | 0.84 | PTGDR2 (0.52) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL2681888 | 0.83 | PTGDR2 (0.59) | PTGDR2CYP2C8CYP2C19CYP2C9 | |
| SCHEMBL12944596 | 0.83 | PTGDR2 (0.55) | PTGDR2CYP2C8CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454243-A2 | TETRAZOLE DERIVATIVES | Merck Serono SA (CH) | 2012-05-23 | — | — | EP | disclosed |
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | TSLP, IL5, CMA1 | PTGDR2 548/4885CYP2C8 108/4885CYP2C19 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.