Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654450 | 0.80 | MTNR1A (0.44) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL5694511 | 0.77 | SMN1; SMN2 (0.49) | KDM4EALDH1A1CA1CA2SMN1; SMN2 | |
| SCHEMBL21676556 | 0.74 | KDM4E (0.51) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL28690878 | 0.73 | MAPT (0.50) | CYP1A2CYP2C19CYP2C9ALDH1A1CA1 | |
| SCHEMBL21464329 | 0.73 | KDM4E (0.51) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL9952903 | 0.73 | KDM4E (0.54) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL382822 | 0.72 | KDM4E (0.66) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL27969533 | 0.72 | KDM4E (0.47) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL22345013 | 0.71 | KDM4E (0.80) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL30009450 | 0.71 | KDM4E (0.80) | KDM4ECYP1A2CYP2C19CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| CN-1005974-B | Process for preparing acid indole compounds | 沃纳·兰伯特公司 | 1989-12-06 | — | — | CN | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| CN-85109061-A | The preparation method of novel acid benzazolyl compounds | — | 1987-01-21 | — | — | CN | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |