Formamide

Formamide

SCHEMBL9540188

CC(C)c1cccnc1C(C)C.NC=O

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.40
GABRA1 P14867 3/20 0.38
GABRB2 P47870 2/20 0.38
CYP3A4 P08684 2/20 0.36
TSHR P16473 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
MEN1 O00255 1/20 0.36
TP53 P04637 1/20 0.36
MAPT P10636 1/20 0.36
NPY1R P25929 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
GABRG2 P18507 2/20 0.34
GABRB3 P28472 2/20 0.34
FAAH O00519 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL269332 0.88 GABRA1 (0.46) CHRNA7GABRA1GABRB2CYP3A4TSHR
Ammonia Solution, Strong SCHEMBL28822995 0.86 GABRA1 (0.44) CHRNA7GABRA1GABRB2CYP3A4TSHR
Alcohol SCHEMBL27794349 0.78 GABRA1 (0.45) CHRNA7GABRA1GABRB2CYP3A4TSHR
Formamide SCHEMBL28288284 0.77 GABRA1 (0.48) GABRA1GABRB2CYP3A4TSHRKMT2A
SCHEMBL25018223 0.76 GABRA1 (0.40) CHRNA7GABRA1GABRB2CYP3A4TSHR
SCHEMBL22961377 0.76 GABRA1 (0.40) CHRNA7GABRA1GABRB2CYP3A4TSHR
SCHEMBL2557955 0.76 TRIM24 (0.53) TSHRTDP1MEN1KMT2ASMN1; SMN2
SCHEMBL22678974 0.76 GABRA1 (0.40) CHRNA7GABRA1GABRB2CYP3A4TSHR
SCHEMBL20350128 0.76 GABRA1 (0.40) CHRNA7GABRA1GABRB2CYP3A4TSHR
SCHEMBL19440375 0.75 GABRA1 (0.33) CHRNA7GABRA1GABRB2CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101160306-B Benzimidazole compounds EISAI R&D MAN CO LTD 2011-11-02 CN disclosed
CN-101160306-A Benzimidazole compounds EISAI R&D MAN CO LTD (JP) 2008-04-09 CN disclosed
EP-0558521-A1 ISONICOTINIC ACID DERIVATIVES AND RELATED SPIRO COMPOUNDS WITH HERBICIDAL ACTION JANSSEN PHARMACEUTICA N.V. (BE) 1993-09-08 EP disclosed