Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538692 | 0.90 | ADORA3 (0.42) | ADORA3HSD17B3KDM4ERAB9AGABRG2 | |
| SCHEMBL9536881 | 0.88 | SMN1; SMN2 (0.41) | ADORA3MAPTALDH1A1GABRG2GABRB3 | |
| SCHEMBL9538271 | 0.87 | ADORA3 (0.40) | ADORA3HSD17B3KDM4EGABRG2GABRB3 | |
| SCHEMBL9538358 | 0.85 | ADORA3 (0.39) | ADORA3HSD17B3MAPTKDM4EGABRG2 | |
| SCHEMBL9537910 | 0.85 | ADORA3 (0.39) | ADORA3HSD17B3MAPTKDM4EGABRG2 | |
| SCHEMBL9537702 | 0.85 | ADORA3 (0.39) | ADORA3HSD17B3GABRG2GABRB3GABRA5 | |
| SCHEMBL9537679 | 0.85 | ADORA3 (0.39) | ADORA3HSD17B3KDM4EGABRG2GABRB3 | |
| SCHEMBL9537279 | 0.84 | ADORA3 (0.43) | ADORA3HSD17B3KDM4EGABRG2GABRB3 | |
| SCHEMBL9537519 | 0.82 | ADORA3 (0.41) | ADORA3HSD17B3MAPTKDM4EGABRG2 | |
| SCHEMBL9537708 | 0.77 | ADORA3 (0.45) | ADORA3HSD17B3MAPTKDM4ENOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |