Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.34 |
| ▸ | CDK2 | P24941 | 5/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL956476 | 0.84 | ALDH1A1 (0.43) | ALDH1A1KDM4ESMN1; SMN2POLBGAA | |
| SCHEMBL6617429 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2POLBGAA | |
| SCHEMBL12798307 | 0.74 | KDM4E (0.47) | ALDH1A1KDM4ESMN1; SMN2PRMT5WDR77 | |
| SCHEMBL953671 | 0.74 | MAPK1 (0.52) | ALDH1A1KDM4ESMN1; SMN2POLBGAA | |
| SCHEMBL15562881 | 0.72 | MEN1 (0.38) | ALDH1A1KDM4ESMN1; SMN2POLBGAA | |
| SCHEMBL477062 | 0.71 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2PRMT5WDR77 | |
| SCHEMBL13122629 | 0.71 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2PRMT5WDR77 | |
| SCHEMBL31001942 | 0.71 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2PRMT5WDR77 | |
| SCHEMBL4052890 | 0.71 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2PRMT5WDR77 | |
| SCHEMBL15690033 | 0.71 | PDE10A (0.45) | ALDH1A1KDM4ESMN1; SMN2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139589-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9090601-B2 | Thiazole derivatives | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| EP-2398796-A1 | HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Canada Inc. (CA) | 2011-12-28 | — | — | EP | disclosed |
| EP-2391619-A1 | HETEROARYLS AND THEIR USE AS PI3K INHIBITORS | Millennium Pharmaceuticals, Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| US-20110003807-A1 | Thiazole derivatives | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-20110003806-A1 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| WO-2010094126-A1 | HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010090716-A1 | HETEROARYLS AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003807-A1 | Thiazole derivatives | MTOR, RICTOR, AKT2 | ALDH1A1 1687/4885KDM4E 1981/4885SMN1; SMN2 3758/4885 |
| US-20110003806-A1 | Heteroaryls and uses thereof | RICTOR, MTOR, AKT1S1 | ALDH1A1 728/4885KDM4E 2304/4885SMN1; SMN2 3959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.