Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218443 | 0.84 | AKR1B1 (0.50) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| Ponalrestat SCHEMBL29498248 | 0.78 | AKR1B1 (1.00) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| Ponalrestat SCHEMBL49154 | 0.78 | AKR1B1 (1.00) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| SCHEMBL9218424 | 0.78 | AKR1B1 (0.70) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| Ponalrestat SCHEMBL30350285 | 0.78 | AKR1B1 (1.00) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| SCHEMBL11175078 | 0.77 | AKR1B1 (0.82) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| Ponalrestat SCHEMBL11166654 | 0.77 | AKR1B1 (0.80) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| Ponalrestat SCHEMBL10702188 | 0.77 | AKR1B1 (0.80) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| SCHEMBL9216124 | 0.76 | AKR1B1 (0.66) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 | |
| SCHEMBL10353490 | 0.76 | AKR1B1 (0.57) | AKR1B1KMT2ACYP1A2CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013092-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | SARGES REINHARD (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5011840-A | Imidazolidinedione derivatives in diabetes treatment | PFIZER INC. (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0269355-B1 | IMIDAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-04-10 | — | — | EP | disclosed |