Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17670777 | 0.77 | ROCK1 (0.47) | HSD17B10NPC1RAB9ATDP1RXFP1 | |
| SCHEMBL9541301 | 0.76 | AKR1B1 (0.64) | AKR1B1KMT2AMEN1HSD17B10CYP1A2 | |
| SCHEMBL25465828 | 0.75 | KMT2A (0.58) | KMT2AMEN1HSP90AA1HSP90AB1TRAP1 | |
| SCHEMBL15720281 | 0.75 | BTK (0.68) | AKR1B1KMT2AMEN1HSD17B10CYP1A2 | |
| SCHEMBL20786971 | 0.74 | TDP1 (0.55) | KMT2AMEN1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL29703239 | 0.73 | TDP1 (0.69) | NPC1RAB9ATDP1RXFP1LMNA | |
| SCHEMBL7894526 | 0.73 | TDP1 (0.69) | NPC1RAB9ATDP1RXFP1LMNA | |
| SCHEMBL9218424 | 0.73 | AKR1B1 (0.70) | AKR1B1KMT2AMEN1HSD17B10CYP1A2 | |
| Ponalrestat SCHEMBL29498248 | 0.73 | AKR1B1 (1.00) | AKR1B1KMT2AMEN1HSD17B10CYP1A2 | |
| Ponalrestat SCHEMBL49154 | 0.73 | AKR1B1 (1.00) | AKR1B1KMT2AMEN1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397930-A1 | Process for the preparation of 3-[(4-bromo-2-fluorophenyl) methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid | MERCK & CO. INC. (US) | 1990-11-22 | — | — | EP | disclosed |
| EP-0322035-A3 | Process for the preparation of 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazine-acetic acid | MERCK & CO. INC. (US) | 1990-08-22 | — | — | EP | disclosed |
| EP-0322035-A2 | Process for the preparation of 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazine-acetic acid | MERCK & CO. INC. (US) | 1989-06-28 | — | — | EP | disclosed |