Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.82 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.82 |
| ▸ | CA12 | O43570 | 1/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.82 |
| ▸ | CA9 | Q16790 | 1/20 | 0.82 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.82 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.53 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.53 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | KDM4B | O94953 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazolinone SCHEMBL88525 | 0.91 | PARP1 (1.00) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL20998623 | 0.89 | PARP1 (0.96) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL8201420 | 0.89 | PARP1 (0.96) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL29603643 | 0.89 | PARP1 (0.96) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL22442340 | 0.89 | PARP1 (0.96) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL30408864 | 0.89 | PARP1 (0.96) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL15691341 | 0.86 | PARP1 (0.82) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL29800668 | 0.84 | PARP1 (0.79) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL31483770 | 0.80 | PARP1 (0.72) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL20788537 | 0.80 | PARP1 (0.66) | PARP1PDPK1CA12ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012795-A1 | QUINAZOLIN-4(3H)-ONE DERIVATIVES AS ANTICOCCIDIAL AGENTS | GLAZER EDWARD A (US) | 1993-07-08 | — | — | WO | disclosed |
| US-4920224-A | CHEMICAL INTERMEDIATES | PFIZER INC. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4849518-A | ANTIPROTOZOA IN POULTRY | PFIZER INC. (US) | 1989-07-18 | — | — | US | disclosed |
| US-4762838-A | Quinazolin-4(3H)-one derivatives as anticoccidial agents | PFIZER INC. (US) | 1988-08-09 | — | — | US | disclosed |