Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11882562 | 0.84 | MDM2 (0.54) | AKR1B1MEN1KMT2AIDO1MDM2 | |
| SCHEMBL9540073 | 0.84 | MEN1 (0.45) | AKR1B1MEN1KMT2AIDO1MAPT | |
| SCHEMBL11392587 | 0.83 | AKR1B1 (0.51) | AKR1B1MEN1KMT2AMAPTBRD4 | |
| SCHEMBL9540134 | 0.83 | AKR1B1 (0.51) | AKR1B1KMT2AMAPTBRD4 | |
| SCHEMBL11388713 | 0.83 | MDM2 (0.46) | AKR1B1MEN1KMT2AIDO1MDM2 | |
| SCHEMBL27311876 | 0.80 | MDM2 (0.55) | MEN1KMT2AIDO1MDM2MAPT | |
| SCHEMBL9541567 | 0.80 | AKR1B1 (0.54) | AKR1B1MEN1KMT2AMDM2MAPT | |
| SCHEMBL9539722 | 0.80 | AKR1B1 (0.50) | AKR1B1IDO1MAPTBRD4 | |
| SCHEMBL9539948 | 0.79 | KDM4E (0.52) | AKR1B1MEN1KMT2AIDO1MAPT | |
| SCHEMBL9539767 | 0.77 | AKR1B1 (0.48) | AKR1B1MEN1KMT2AIDO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530994-A1 | Quinazoline derivatives as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1993004047-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-04 | — | — | WO | disclosed |
| US-4258187-A | REACTING 2-AMINO-BENZOPHENONE DERIVATIVES WITH A HYDROXYLAMINE SALT | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-03-24 | — | — | US | disclosed |
| EP-0000149-A1 | Process for preparing quinazolinone oxides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-01-10 | — | — | EP | disclosed |