Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 2/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15257085 | 0.81 | MAPT (0.53) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL1464982 | 0.80 | GAA (0.51) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL29544600 | 0.78 | HTT (0.62) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL17099508 | 0.77 | MEN1 (0.44) | MEN1KMT2AHTTLMNAMAPT | |
| SCHEMBL2122759 | 0.75 | CYP19A1 (0.59) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL3010106 | 0.75 | HTT (0.52) | KMT2AHTTMAPTALDH1A1HPGD | |
| SCHEMBL19669453 | 0.74 | MAPT (0.51) | MEN1KMT2AHTTLMNAMAPT | |
| SCHEMBL1026633 | 0.73 | MAPT (0.50) | MEN1KMT2AHTTLMNAMAPT | |
| SCHEMBL1026631 | 0.73 | MAPT (0.50) | MEN1KMT2AHTTLMNAMAPT | |
| SCHEMBL28995799 | 0.73 | MAPK1 (0.43) | MEN1KMT2AHTTMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993010119-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-05-27 | — | — | WO | disclosed |
| EP-0542497-A1 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-05-19 | — | — | EP | disclosed |