Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8844508 | 0.84 | NPC1 (0.69) | NPC1RAB9AGAANPY2RSMN1; SMN2 | |
| SCHEMBL9542192 | 0.82 | GAA (0.75) | NPC1RAB9AGAANPY2RSMN1; SMN2 | |
| SCHEMBL9542252 | 0.82 | NPC1 (0.69) | NPC1RAB9AGAANPY2RSMN1; SMN2 | |
| SCHEMBL9542231 | 0.81 | NPC1 (0.64) | NPC1RAB9AGAANPY2RSMN1; SMN2 | |
| SCHEMBL27852182 | 0.80 | GAA (0.63) | NPC1RAB9AGAANPY2RSMN1; SMN2 | |
| SCHEMBL8845027 | 0.80 | NPC1 (0.71) | NPC1RAB9AGAANPY2RHSD17B10 | |
| SCHEMBL8844754 | 0.80 | NPC1 (0.63) | NPC1RAB9AGAANPY2R | |
| SCHEMBL9541815 | 0.79 | NPC1 (0.56) | NPC1RAB9AGAANPY2RALDH1A1 | |
| SCHEMBL9544582 | 0.79 | NPC1 (0.64) | NPC1RAB9AGAASMN1; SMN2MEN1 | |
| SCHEMBL9543461 | 0.79 | NPC1 (0.64) | NPC1RAB9AGAANPY2RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013067-A1 | 4-SUBSTITUTED PIPERIDINECARBOXYLIC ACID ESTERS: INHIBITION OF CHOLESTEROL ABSORPTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-07-08 | — | — | WO | claimed |
| US-5169844-A | Enzyme inhibitor, anticholesterol and antilipemic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-08 | — | — | US | claimed |
| US-5169844-A | Enzyme inhibitor, anticholesterol and antilipemic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |