Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 4/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541675 | 0.81 | PGR (0.35) | PGRALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL9539196 | 0.77 | PDE7A (0.49) | MEN1KMT2AIDO1 | |
| SCHEMBL9539898 | 0.70 | PDE7A (0.47) | MEN1KMT2AIDO1HTR7 | |
| SCHEMBL9539079 | 0.66 | AKR1B1 (0.48) | MEN1KMT2AIDO1TSHRHTR7 | |
| SCHEMBL9540069 | 0.65 | MEN1 (0.41) | MEN1KMT2AIDO1TSHRHTR7 | |
| SCHEMBL27372550 | 0.64 | MEN1 (0.34) | MEN1KMT2AIDO1HTR7CYP46A1 | |
| SCHEMBL9541537 | 0.64 | PDE7A (0.46) | PGRMEN1KMT2AIDO1HTR7 | |
| SCHEMBL9571241 | 0.64 | PDE7A (0.49) | MEN1KMT2AIDO1 | |
| SCHEMBL9539061 | 0.63 | MEN1 (0.39) | MEN1KMT2AIDO1HTR7CYP46A1 | |
| SCHEMBL9539949 | 0.62 | PDE7A (0.47) | PGRMEN1KMT2ACYP46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530994-A1 | Quinazoline derivatives as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1993004047-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-04 | — | — | WO | disclosed |