Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5636105 | 0.84 | MAPT (0.46) | MAPTBRD4S1PR1S1PR5PDK1 | |
| SCHEMBL8556520 | 0.84 | ACHE (0.46) | MAPTBRD4DRD2DRD3ALDH1A1 | |
| SCHEMBL1717026 | 0.81 | MAPT (0.59) | MAPTBRD4S1PR1S1PR5PDK1 | |
| SCHEMBL27923154 | 0.78 | S1PR5 (0.42) | MAPTBRD4S1PR1S1PR5PDK1 | |
| SCHEMBL2280754 | 0.77 | MAPT (0.63) | MAPTDRD2DRD3 | |
| SCHEMBL2282579 | 0.77 | MAPT (0.63) | MAPTDRD2DRD3 | |
| SCHEMBL2280757 | 0.77 | MAPT (0.63) | MAPTDRD2DRD3 | |
| SCHEMBL22038592 | 0.77 | MAPT (0.62) | MAPTDRD2DRD3 | |
| SCHEMBL17986812 | 0.77 | MAPT (0.58) | MAPTBRD4S1PR1S1PR5PDK1 | |
| SCHEMBL20135465 | 0.77 | MAPT (0.58) | MAPTBRD4S1PR1S1PR5PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103354742-A | Novel oxime azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators | ALLERGAN INC | 2013-10-16 | — | — | CN | claimed |
| CN-103354742-A | Novel oxime azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators | ALLERGAN INC | 2013-10-16 | — | — | CN | disclosed |
| WO-1993003725-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-04 | — | — | WO | disclosed |