Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467889 | 1.00 | ADRB2 (0.73) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL4467885 | 1.00 | ADRB2 (0.73) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL9467104 | 0.95 | ADRB2 (0.68) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL11467407 | 0.91 | ADRB2 (0.61) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL11467406 | 0.91 | ADRB2 (0.61) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL10720145 | 0.90 | ADRB2 (0.77) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| Bromide SCHEMBL11470044 | 0.89 | ADRB2 (0.59) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| Bromide SCHEMBL11470045 | 0.89 | ADRB2 (0.59) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL19245594 | 0.86 | ADRB2 (0.71) | ADRB2KDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL19245591 | 0.86 | ADRB2 (0.71) | ADRB2KDM4EGAASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516826-A | Beta-3 receptor ligands and therapeutic uses thereof | UNIV BARI (IT) | 2009-08-26 | — | — | CN | claimed |
| CN-101516826-B | Beta-3 receptor ligands | UNIV BARI | 2015-03-04 | — | — | CN | disclosed |
| CN-101516826-A | Beta-3 receptor ligands and therapeutic uses thereof | UNIV BARI (IT) | 2009-08-26 | — | — | CN | disclosed |
| WO-1993010074-A1 | ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS BETA-3-ADRENOCEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |