SCHEMBL9543573

SCHEMBL9543573

CC(=O)O[C@@]1(C)CC[C@H]2[C@@H]3CCC4=C(C)C(=O)CC[C@]4(C)[C@H]3CC[C@@]21C

nearest known ligand 0.59

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.59
SHBG P04278 1/20 0.57
CYP17A1 P05093 1/20 0.56
CYP19A1 P11511 14/20 0.52
TSHR P16473 1/20 0.47
THPO P40225 1/20 0.47
HIF1A Q16665 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9543581 1.00 CYP3A4 (0.59) CYP3A4SHBGCYP17A1CYP19A1TSHR
SCHEMBL9542059 0.88 CYP19A1 (0.60) CYP3A4SHBGCYP17A1CYP19A1TSHR
SCHEMBL9542062 0.88 CYP19A1 (0.60) CYP3A4SHBGCYP17A1CYP19A1TSHR
SCHEMBL9541266 0.86 CYP17A1 (0.51) CYP3A4SHBGCYP17A1CYP19A1TSHR
SCHEMBL9541909 0.81 CYP17A1 (0.46) CYP3A4SHBGCYP17A1CYP19A1TSHR
SCHEMBL9542566 0.81 CYP3A4 (0.67) CYP3A4SHBGCYP19A1TSHRTHPO
SCHEMBL9542574 0.81 CYP3A4 (0.67) CYP3A4SHBGCYP19A1TSHRTHPO
SCHEMBL9542435 0.80 CYP17A1 (0.46) CYP3A4SHBGCYP17A1CYP19A1TSHR
SCHEMBL10771342 0.79 SHBG (0.65) CYP3A4SHBGCYP19A1TSHRTHPO
SCHEMBL9541156 0.77 CYP17A1 (0.70) CYP3A4SHBGCYP17A1TSHRTHPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993013122-A1 3-METHYLSULPHONYLHYDRAZONO AND 3-OXYIMINO STEROIDS, A METHOD OF PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PREPARATION OF DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-07-08 WO disclosed