SCHEMBL9545022

SCHEMBL9545022

COc1ccc([C@@H]2CC[C@H](C(=O)O)N2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 11/20 0.56
SCN3A Q9NY46 7/20 0.56
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
SCN9A Q15858 2/20 0.45
SCN1A P35498 1/20 0.44
SCN4A P35499 1/20 0.44
SCN7A Q01118 1/20 0.44
SCN5A Q14524 1/20 0.44
SCN2A Q99250 1/20 0.44
SCN8A Q9UQD0 1/20 0.44
SCN10A Q9Y5Y9 1/20 0.44
EDNRB P24530 1/20 0.44
EDNRA P25101 1/20 0.44
S1PR4 O95977 2/20 0.44
S1PR1 P21453 2/20 0.44
S1PR5 Q9H228 2/20 0.44
S1PR3 Q99500 1/20 0.44
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31370338 0.82 KDM4E (0.54) KCNH2SCN3ACYP2C9S1PR4S1PR1
SCHEMBL7775270 0.82 KDM4E (0.54) KCNH2SCN3ACYP2C9S1PR4S1PR1
SCHEMBL7775272 0.82 KDM4E (0.54) KCNH2SCN3ACYP2C9S1PR4S1PR1
SCHEMBL4712198 0.81 KCNH2 (0.57) KCNH2SCN3A
SCHEMBL135106 0.80 KCNH2 (0.56) KCNH2SCN3ASCN9ASCN1ASCN4A
SCHEMBL135105 0.80 KCNH2 (0.56) KCNH2SCN3ASCN9ASCN1ASCN4A
SCHEMBL1226045 0.80 KCNH2 (0.56) KCNH2SCN3ASCN9ASCN1ASCN4A
SCHEMBL197791 0.80 KCNH2 (0.56) KCNH2SCN3ASCN9ASCN1ASCN4A
SCHEMBL5696388 0.80 KCNH2 (0.56) KCNH2SCN3ASCN9ASCN1ASCN4A
SCHEMBL197425 0.80 KCNH2 (0.56) KCNH2SCN3ASCN9ASCN1ASCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993020099-A2 CCK AND/OR GASTRIN RECEPTOR LIGANDS FERRING B.V. (NL) 1993-10-14 WO disclosed