Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.50 |
| ▸ | BCHE | P06276 | 5/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9547699 | 0.89 | ACHE (0.60) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL8634850 | 0.75 | — | — | |
| SCHEMBL9547713 | 0.72 | ACHE (0.55) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL19643085 | 0.70 | DPP4 (0.39) | CHRM1 | |
| SCHEMBL4271238 | 0.68 | ACHE (1.00) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL5682854 | 0.68 | ACHE (0.94) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL5487183 | 0.68 | ACHE (0.59) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL9547666 | 0.68 | ACHE (0.62) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL9547682 | 0.67 | ACHE (0.58) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL7382874 | 0.67 | ACHE (0.46) | ACHEBCHECHRM1EPHX2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369388-B1 | HYDROXY-1,2,3,4-TETRAHYDROAMINOACRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0369388-A1 | Hydroxy-1,2,3,4-tetrahydroaminoacridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-05-23 | — | — | EP | disclosed |