Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Tetraphenylphosphonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraphenylphosphonium SCHEMBL42616 | 0.93 | HIF1A (0.47) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL17818165 | 0.93 | HIF1A (0.47) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL585136 | 0.93 | HIF1A (0.47) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL7906432 | 0.90 | HIF1A (0.45) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL3304548 | 0.90 | HIF1A (0.45) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL3300848 | 0.90 | HIF1A (0.45) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL17263861 | 0.90 | HIF1A (0.45) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL22151013 | 0.90 | HIF1A (0.45) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL7062601 | 0.90 | HIF1A (0.45) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 | |
| Tetraphenylphosphonium SCHEMBL7931760 | 0.90 | HIF1A (0.45) | HIF1AALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289942-B1 | PROCESS FOR PRODUCING FLUOROBENZALDEHYDES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1993-07-07 | — | — | EP | disclosed |