Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TRHR | P34981 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9548200 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2APOLBMC4R | |
| SCHEMBL17484763 | 0.90 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL9548205 | 0.90 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL9548201 | 0.90 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL9548183 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APOLBMC4R | |
| SCHEMBL9548182 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APOLBMC4R | |
| SCHEMBL26508171 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APOLBPRCP | |
| SCHEMBL26508419 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APOLBPRCP | |
| SCHEMBL26508178 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APOLBPRCP | |
| SCHEMBL7519164 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227496-A | PYROGLUTAMIC ACID DERIVATIVES AS ENHANCERS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1993-07-13 | — | — | US | disclosed |
| EP-0511943-A2 | Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1992-11-04 | — | — | EP | disclosed |