Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9548278 | 0.84 | PPARA (0.52) | PPARASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL4167077 | 0.77 | PPARA (0.42) | PPARASMN1; SMN2RAB9ANPC1KMT2A | |
| Hydrochloric Acid SCHEMBL9548291 | 0.76 | PPARA (0.41) | PPARASMN1; SMN2RAB9ANOTUMATM | |
| Hydrochloric Acid SCHEMBL9548262 | 0.74 | PPARA (0.41) | PPARASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL9548330 | 0.74 | NOTUM (0.43) | PPARASMN1; SMN2NOTUMALDH1A1HPGD | |
| SCHEMBL11661758 | 0.72 | PPARA (0.60) | PPARASMN1; SMN2RAB9ANPC1MMP2 | |
| SCHEMBL9849583 | 0.70 | NOTUM (0.42) | PPARANOTUM | |
| SCHEMBL13268368 | 0.70 | PPARA (0.48) | PPARASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL9849445 | 0.70 | PPARA (0.51) | PPARASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL12334223 | 0.69 | PPARA (0.45) | PPARASMN1; SMN2RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | claimed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | claimed |
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | disclosed |