Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | LDHB | P07195 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198665 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBALDH1A1FDPSNPC1 | |
| SCHEMBL8283554 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBALDH1A1FDPSNPC1 | |
| SCHEMBL9548373 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL9548380 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL6821314 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL15932023 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2POLBCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL15931909 | 0.75 | DAO (0.48) | SMN1; SMN2POLBALDH1A1FDPSNPC1 | |
| Bicarbonate SCHEMBL23420914 | 0.73 | HDAC8 (0.64) | SMN1; SMN2MEN1KMT2ACA1CA2 | |
| Bicarbonate SCHEMBL11577277 | 0.73 | HDAC8 (0.64) | SMN1; SMN2MEN1KMT2ACA1CA2 | |
| SCHEMBL15931916 | 0.73 | PTPN1 (0.53) | SMN1; SMN2POLBALDH1A1FDPSHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | disclosed |