SCHEMBL9548676

SCHEMBL9548676

N#C[C@]1(CO)O[C@@H](n2cnc3c(N)nc(N)nc32)C[C@@H]1O

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AHCY P23526 3/20 0.50
PNP P00491 1/20 0.44
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
HTT P42858 1/20 0.44
PDE4D Q08499 1/20 0.44
PDE3A Q14432 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
ADORA2A P29274 1/20 0.40
HSP90B1 P14625 2/20 0.40
ADORA3 P0DMS8 2/20 0.39
HSP90AA1 P07900 1/20 0.39
SLC28A1 O00337 1/20 0.39
SLC28A2 O43868 1/20 0.39
NT5E P21589 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9548688 1.00 AHCY (0.50) AHCYPNPLMNATP53HTT
SCHEMBL12237558 1.00 AHCY (0.50) AHCYPNPLMNATP53HTT
SCHEMBL30662535 0.91 AHCY (0.49) AHCYPNPLMNATP53HTT
SCHEMBL2524218 0.91 AHCY (0.49) AHCYPNPLMNATP53HTT
SCHEMBL12238023 0.91 AHCY (0.49) AHCYPNPLMNATP53HTT
SCHEMBL12214156 0.91 AHCY (0.49) AHCYPNPLMNATP53HTT
SCHEMBL31653046 0.91 AHCY (0.49) AHCYPNPLMNATP53HTT
SCHEMBL7210684 0.91 AHCY (0.49) AHCYPNPLMNATP53HTT
SCHEMBL2523178 0.90 AHCY (0.52) AHCYPNPLMNATP53HTT
SCHEMBL2523180 0.90 AHCY (0.52) AHCYPNPLMNATP53HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230293526-A1 METHOD FOR TREATING CANCER WITH A REVERSE TRANSCRIPTASE INHIBITOR PRIMEFOUR THERAPEUTICS, INC. 2023-09-21 US disclosed
WO-2022256625-A1 LINE-1 INHIBITORS AS COGNITIVE ENHANCERS TRANSPOSON THERAPEUTICS, INC. (US) 2022-12-08 WO disclosed
US-5192749-A Viricide, AIDS SYNTEX (U.S.A.) INC. (US) 1993-03-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230293526-A1 METHOD FOR TREATING CANCER WITH A REVERSE TRANSCRIPTASE INHIBITOR TYMP, TYMS, DCTD AHCY 248/4885PNP 50/4885LMNA 3687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.