Carubicin

Carubicin

SCHEMBL9552

CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1c(O)cccc1C3=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 9/20 1.00
THRB P10828 9/20 1.00
KMT2A Q03164 9/20 1.00
BLM P54132 8/20 1.00
RECQL P46063 7/20 1.00
MAPT P10636 6/20 1.00
HTT P42858 5/20 1.00
TDP1 Q9NUW8 5/20 1.00
APEX1 P27695 3/20 1.00
BRCA1 P38398 6/20 0.87
SMN1; SMN2 Q16637 6/20 0.87
HIF1A Q16665 6/20 0.87
MAPK1 P28482 5/20 0.87
S100A4 P26447 5/20 0.87
CYP3A4 P08684 4/20 0.87
USP2 O75604 4/20 0.87
CYP1A2 P05177 4/20 0.87
CHRM1 P11229 4/20 0.87
TOP2A P11388 4/20 0.87
STAT6 P42226 4/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carubicin SCHEMBL6343014 1.00 MEN1 (1.00) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL29362266 1.00 MEN1 (1.00) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL12202628 1.00 MEN1 (1.00) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL6343007 1.00 MEN1 (1.00) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL1650594 1.00 MEN1 (1.00) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL23300868 1.00 MEN1 (1.00) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL18389599 1.00 MEN1 (1.00) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL29357994 0.99 MEN1 (0.98) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL29355094 0.99 MEN1 (0.98) MEN1THRBKMT2ABLMRECQL
Carubicin SCHEMBL4201 0.99 MEN1 (0.98) MEN1THRBKMT2ABLMRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 24493 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
US-20260137794-A1 LIGAND-DRUG CONJUGATE AND USE THEREOF SYSTIMMUNE INC (US) 2026-05-21 US claimed
US-12630593-B2 Method of killing leukemia cells by administration of recombinant'Y3 proteins UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-19 US claimed
US-20260115305-A1 LINKERS, CONJUGATES AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2026-04-30 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-20260077056-A1 LINKER-PAYLOAD COMPOUND, CONJUGATES AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2026-03-19 US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
EP-4694909-A1 METHODS OF MODULATING THE EPITHELIAL-MESENCHYMAL TRANSITION RS Oncology, LLC (US) 2026-02-18 EP claimed
EP-4694935-A1 COMBINATION OF ANTIBODY-DRUG CONJUGATE AND ANTI-PD-1 ANTIBODY, AND USE THEREOF Genequantum Healthcare (Suzhou) Co., Ltd. (CN) 2026-02-18 EP claimed
EP-4688871-A1 SITE-SPEICFIC ORTHOGONAL BIOCONJUGATE MODALITY AND APPLICATION THEREOF Genequantum Healthcare (Suzhou) Co., Ltd. (CN) 2026-02-11 EP claimed
EP-0398305-A2 Anthracycline conjugates having a novel linker and methods for their production Bristol-Myers Squibb Company (US) 1990-11-22 EP claimed
EP-0226173-B1 ANTHRACYCLINS AND MEDICINES CONTAINING THEM LABORATOIRES HOECHST S.A. (FR) 1990-03-14 EP claimed
US-4877870-A HYDROXYLATION; REACTING WITH AMINE OXIDE; ANTITUMOR AGENTS KIRIN BEER KABUSHIKI KAISHA (JP) 1989-10-31 US claimed
EP-0328147-A2 Anthracycline immunoconjugates having a novel linker and methods for their production Bristol-Myers Squibb Company (US) 1989-08-16 EP claimed
EP-0302473-A2 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells Bristol-Myers Squibb Company (US) 1989-02-08 EP claimed
EP-0226173-A1 Anthracyclins and medicines containing them LABORATOIRES HOECHST S.A. (FR) 1987-06-24 EP claimed
US-4331648-A CARDIOTONIC AGENTS; MOUTH THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1982-05-25 US claimed
US-4320110-A Carnitine and its use in reducing cardiac toxicity and as a synergist with cytostats FELICE STEPHEN L DE 1982-03-16 US claimed
US-4189568-A MULTISTEP SOLVENT EXTRACTION OF FERMEMTATION SOLIDS, COUNTERCURRENT DISTRIBUTION, CHROMATOGRAPHY BRISTOL-MYERS COMPANY (US) 1980-02-19 US claimed
US-4188377-A TREATMENT OF LEUKEMIA; SYNTHETIC ANTHRACYCLINE ANTIBIOTIC HAVING LOWERED TOXICITY FARMITALIA CARLO ERBA S.P.A. (IT) 1980-02-12 US claimed