Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC33A1 | O00400 | 4/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9552997 | 0.96 | SLC33A1 (0.37) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9552173 | 0.93 | PDE5A (0.37) | SLC33A1AGTR1AGTR2PDE5APDE1A | |
| SCHEMBL9553593 | 0.90 | SLC33A1 (0.36) | SLC33A1AGTR1AGTR2PDE5APDE1A | |
| SCHEMBL9739892 | 0.87 | SLC33A1 (0.37) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9739582 | 0.86 | SLC33A1 (0.36) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9738379 | 0.85 | SLC33A1 (0.36) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9552810 | 0.85 | AGTR1 (0.42) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9552812 | 0.85 | SLC33A1 (0.38) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9738367 | 0.85 | SLC33A1 (0.35) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9553152 | 0.84 | AGTR1 (0.49) | SLC33A1AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229406-A | Treatment of glaucoma | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5140036-A | Hypotensive agents; congestive heart failure; angiotensin antagonists | G. D. SEARLE & CO. (US) | 1992-08-18 | — | — | US | disclosed |
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | disclosed |