Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | SLC33A1 | O00400 | 2/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9552499 | 0.95 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9552383 | 0.94 | AGTR1 (0.43) | AGTR1SLC33A1AGTR2 | |
| SCHEMBL9552739 | 0.94 | SLC33A1 (0.38) | AGTR1SLC33A1AGTR2 | |
| SCHEMBL9552150 | 0.94 | AGTR1 (0.43) | AGTR1SLC33A1AGTR2 | |
| SCHEMBL9552663 | 0.91 | TRPV1 (0.36) | AGTR1SLC33A1AGTR2 | |
| SCHEMBL7341926 | 0.91 | AGTR1 (0.33) | AGTR1SLC33A1AGTR2 | |
| SCHEMBL7335539 | 0.91 | AGTR1 (0.32) | AGTR1SLC33A1 | |
| SCHEMBL9552897 | 0.90 | AGTR1 (0.34) | AGTR1SLC33A1AGTR2 | |
| SCHEMBL7346513 | 0.90 | AGTR1 (0.32) | AGTR1SLC33A1AGTR2 | |
| SCHEMBL7343133 | 0.90 | AGTR1 (0.33) | AGTR1SLC33A1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229406-A | Treatment of glaucoma | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5140036-A | Hypotensive agents; congestive heart failure; angiotensin antagonists | G. D. SEARLE & CO. (US) | 1992-08-18 | — | — | US | disclosed |
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | disclosed |