Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 16/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | VCP | P55072 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | PNP | P00491 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555507 | 1.00 | HPRT1 (0.58) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9417201 | 1.00 | HPRT1 (0.58) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9417143 | 0.88 | MEN1 (0.52) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9858092 | 0.84 | HPRT1 (0.66) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL84257 | 0.83 | HPRT1 (0.81) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9175736 | 0.83 | HPRT1 (0.81) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL173060 | 0.83 | HPRT1 (0.81) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9858169 | 0.82 | HPRT1 (0.73) | HPRT1PNP | |
| SCHEMBL9417147 | 0.82 | CYP3A4 (0.42) | HPRT1MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9684414 | 0.82 | HPRT1 (0.56) | HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5247085-A | Phosphonate containing purine compounds | BEECHAM GROUP P.L.C. (GB) | 1993-09-21 | — | — | US | claimed |
| EP-0405748-A1 | Phosphonoderivative of purine with antiviral activity | Beecham Group p.l.c. (GB) | 1991-01-02 | — | — | EP | claimed |
| JP-3017090-A | — | — | None | — | — | JP | disclosed |
| US-5247085-A | Phosphonate containing purine compounds | BEECHAM GROUP P.L.C. (GB) | 1993-09-21 | — | — | US | disclosed |
| JP-H0317090-A | NOVEL COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUND | BEECHAM GROUP PLC | 1991-01-25 | — | — | JP | disclosed |
| EP-0405748-A1 | Phosphonoderivative of purine with antiviral activity | Beecham Group p.l.c. (GB) | 1991-01-02 | — | — | EP | disclosed |