Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | AHCY | P23526 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417199 | 0.87 | CDK1 (0.39) | CYP3A4FGFR1NT5EHPRT1CDK1 | |
| SCHEMBL9417190 | 0.86 | CYP3A4 (0.55) | CYP3A4FGFR1SLC22A6AHCY | |
| SCHEMBL9555809 | 0.86 | CYP3A4 (0.55) | CYP3A4FGFR1SLC22A6AHCY | |
| SCHEMBL9555564 | 0.86 | CYP3A4 (0.55) | CYP3A4FGFR1SLC22A6AHCY | |
| SCHEMBL9858340 | 0.83 | HPRT1 (0.43) | CYP3A4FGFR1SLC22A6NT5EHPRT1 | |
| SCHEMBL29450587 | 0.82 | HPRT1 (0.55) | CYP3A4FGFR1SLC22A6HPRT1CDK1 | |
| SCHEMBL15516660 | 0.82 | HPRT1 (0.55) | CYP3A4FGFR1SLC22A6HPRT1CDK1 | |
| SCHEMBL172847 | 0.82 | HPRT1 (0.55) | CYP3A4FGFR1SLC22A6HPRT1CDK1 | |
| SCHEMBL9555352 | 0.82 | HPRT1 (0.58) | CYP3A4HPRT1MEN1ALDH1A1LMNA | |
| SCHEMBL9555507 | 0.82 | HPRT1 (0.58) | CYP3A4HPRT1MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319228-B1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1994-11-02 | — | — | EP | claimed |
| US-5247085-A | Phosphonate containing purine compounds | BEECHAM GROUP P.L.C. (GB) | 1993-09-21 | — | — | US | claimed |
| EP-0319228-B1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| US-5247085-A | Phosphonate containing purine compounds | BEECHAM GROUP P.L.C. (GB) | 1993-09-21 | — | — | US | disclosed |
| EP-0319228-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1989-06-07 | — | — | EP | disclosed |