Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMD1 | P17707 | 3/20 | 0.68 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.57 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 8/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.53 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.52 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL952230 | 0.91 | AMD1 (0.82) | AMD1EZH2DOT1LTAS1R3TAS1R1 | |
| SCHEMBL951634 | 0.90 | AMD1 (0.76) | AMD1EZH2DOT1LTAS1R3TAS1R1 | |
| SCHEMBL953623 | 0.90 | AMD1 (0.63) | AMD1EZH2DOT1LTAS1R3TAS1R1 | |
| Sulfuric Acid SCHEMBL955704 | 0.89 | AMD1 (0.81) | AMD1EZH2DOT1LPRMT1CARM1 | |
| Sulfuric Acid SCHEMBL955710 | 0.89 | AMD1 (0.81) | AMD1EZH2DOT1LPRMT1CARM1 | |
| SCHEMBL952790 | 0.87 | AMD1 (0.60) | AMD1EZH2DOT1LTAS1R3TAS1R1 | |
| SCHEMBL956819 | 0.86 | AMD1 (0.80) | AMD1 | |
| SCHEMBL995958 | 0.86 | AMD1 (0.77) | AMD1EZH2DOT1LPRMT1CARM1 | |
| Water SCHEMBL10664708 | 0.85 | AMD1 (0.76) | AMD1EZH2DOT1LPRMT1CARM1 | |
| SCHEMBL952746 | 0.84 | AMD1 (0.69) | AMD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | claimed |
| EP-2170057-A1 | 5'-SUBSTITUTED ADENOSYNES, PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | Southern Research Institute (US) | 2010-04-07 | — | — | EP | claimed |
| WO-2009018541-A1 | 5'-SUBSTITUTED ADENOSYNES, PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | SOUTHERN RESEARCH INSTITUTE (US) | 2009-02-05 | — | — | WO | claimed |
| US-8637485-B2 | 5′,-substituted adenosynes preparation thereof and use as inhibitors of S-adenosylmethionine decarboxylase | SOUTHERN RESEARCH INSTITUTE (US) | 2014-01-28 | — | — | US | disclosed |
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | disclosed |
| EP-2170057-A1 | 5'-SUBSTITUTED ADENOSYNES, PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | Southern Research Institute (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009018541-A1 | 5'-SUBSTITUTED ADENOSYNES, PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | SOUTHERN RESEARCH INSTITUTE (US) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | AMD1, ADA, MTAP | AMD1 1/4885EZH2 370/4885DOT1L 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.