SCHEMBL9557231

SCHEMBL9557231

N#CC(CCc1cccc(C(F)(F)F)c1)(Cn1cncn1)c1ccccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.39
UGT1A4 P22310 1/20 0.38
PDE4D Q08499 1/20 0.38
KDM4E B2RXH2 1/20 0.38
ALOX15 P16050 1/20 0.38
HSP90AA1 P07900 1/20 0.37
CYP3A4 P08684 2/20 0.36
ALDH1A1 P00352 1/20 0.36
MIF P14174 1/20 0.35
P2RX7 Q99572 1/20 0.35
MAOB P27338 1/20 0.35
TAAR1 Q96RJ0 1/20 0.34
AR P10275 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9557887 0.89 KDM4E (0.38) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9556996 0.88 HSP90AA1 (0.43) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557573 0.87 CYP19A1 (0.43) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557099 0.87 ALDH1A1 (0.43) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557465 0.87 CYP19A1 (0.40) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557593 0.85 KDM4E (0.39) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557305 0.84 HSP90AA1 (0.43) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557220 0.83 KMT2A (0.41) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557492 0.83 KDM4E (0.39) CYP19A1UGT1A4PDE4DKDM4EALOX15
SCHEMBL9557004 0.83 CYP3A4 (0.43) CYP19A1UGT1A4PDE4DKDM4EHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251775-B1 ALPHA-ARYL-ALPHA-PHENYLETHYL-1H-1,2,4-TRIAZOLE-1-PROPANENITRILES ROHM AND HAAS COMPANY (US) 1993-01-20 EP disclosed
US-5087635-A Funcicides ROHM AND HAAS COMPANY (US) 1992-02-11 US disclosed
EP-0251775-A2 Alpha-aryl-alpha-phenylethyl-1H-1,2,4-triazole-1-propanenitriles ROHM AND HAAS COMPANY (US) 1988-01-07 EP disclosed