Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | UCHL3 | P15374 | 2/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10025241 | 0.71 | PTGDR2 (0.74) | PTGDR2AKR1B1 | |
| SCHEMBL958668 | 0.70 | PTGDR2 (1.00) | PTGDR2AKR1B1 | |
| SCHEMBL954381 | 0.70 | PTGDR2 (0.67) | PTGDR2AKR1B1 | |
| SCHEMBL11959126 | 0.66 | PTGDR2 (0.75) | PTGDR2AKR1B1 | |
| SCHEMBL6127700 | 0.66 | PTGDR2 (0.61) | PTGDR2AKR1B1 | |
| SCHEMBL2483180 | 0.64 | PTGDR2 (1.00) | PTGDR2AKR1B1 | |
| SCHEMBL2486352 | 0.64 | PTGDR2 (0.62) | PTGDR2AKR1B1 | |
| SCHEMBL2484248 | 0.58 | PTGDR2 (0.64) | PTGDR2 | |
| SCHEMBL11959124 | 0.58 | PTGDR2 (0.59) | PTGDR2 | |
| SCHEMBL10025212 | 0.58 | PTGDR2 (1.00) | PTGDR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006936-A1 | TRICYCLIC INDOLE-DERIVED SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |