Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685018 | 0.81 | PTGDR2 (0.69) | PTGDR2AKR1B1 | |
| SCHEMBL958668 | 0.81 | PTGDR2 (1.00) | PTGDR2AKR1B1 | |
| SCHEMBL10025241 | 0.79 | PTGDR2 (0.74) | PTGDR2AKR1B1 | |
| SCHEMBL2481296 | 0.77 | PTGDR2 (0.66) | PTGDR2AKR1B1 | |
| SCHEMBL2483180 | 0.74 | PTGDR2 (1.00) | PTGDR2AKR1B1 | |
| SCHEMBL11959126 | 0.73 | PTGDR2 (0.75) | PTGDR2AKR1B1 | |
| SCHEMBL2486611 | 0.71 | PTGDR2 (0.59) | PTGDR2 | |
| SCHEMBL2486352 | 0.71 | PTGDR2 (0.62) | PTGDR2AKR1B1 | |
| SCHEMBL958583 | 0.70 | PTGDR2 (0.38) | PTGDR2AKR1B1 | |
| SCHEMBL955786 | 0.70 | PTGDR2 (0.54) | PTGDR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115895-A1 | TRICYCLIC INDOLE-DERIVED SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
| EP-1891075-B1 | TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO SA (CH) | 2011-10-19 | — | — | EP | disclosed |
| WO-2011006936-A1 | TRICYCLIC INDOLE-DERIVED SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115895-A1 | TRICYCLIC INDOLE-DERIVED SPIRO DERIVATIVES AS CRTH2 MODULATORS | HRH2, HRH1, LTC4S | PTGDR2 53/4885AKR1B1 905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.