Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 9/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507048 | 0.81 | PPARA (0.60) | PPARAMAOBPPARD | |
| SCHEMBL9558448 | 0.80 | PPARA (0.52) | PPARAMAOBPPARD | |
| SCHEMBL9557961 | 0.79 | PPARA (0.54) | PPARAMAOBMAOAPPARD | |
| SCHEMBL9557975 | 0.78 | PDE5A (0.52) | PPARAPPARD | |
| SCHEMBL9558413 | 0.77 | PDE5A (0.51) | PPARAPPARD | |
| SCHEMBL9304221 | 0.75 | PPARA (0.67) | PPARAPPARD | |
| SCHEMBL8064862 | 0.75 | PPARD (0.52) | MAOBMAOAPPARD | |
| SCHEMBL8063478 | 0.74 | PPARA (0.69) | PPARA | |
| SCHEMBL9304111 | 0.74 | PPARA (0.69) | PPARA | |
| SCHEMBL9305947 | 0.73 | CA12 (0.51) | MAOBMAOAPPARDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384350-B1 | DIHYDROXY NAPHTHALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| EP-0384350-A1 | Dihydroxy naphthalene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |
| US-4937371-A | INHIBITING LIPOXYGENASE | HOFFMANN-LA ROCHE INC. (US) | 1990-06-26 | — | — | US | disclosed |