Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.38 |
| ▸ | SLC13A2 | Q13183 | 1/20 | 0.38 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957378 | 1.00 | ERN1 (0.44) | ERN1SRCALDH1A1KDM4ETSHR | |
| SCHEMBL19330147 | 0.81 | ERN1 (0.46) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL29951175 | 0.79 | ERN1 (0.46) | ERN1SRCALDH1A1KDM4ETSHR | |
| SCHEMBL671095 | 0.79 | ERN1 (0.46) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL1116679 | 0.79 | ERN1 (0.38) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL5784164 | 0.79 | ERN1 (0.46) | ERN1SRCALDH1A1KDM4ETSHR | |
| SCHEMBL19330137 | 0.79 | TRIM24 (0.44) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL31029519 | 0.79 | TRIM24 (0.44) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL29490119 | 0.79 | ERN1 (0.38) | ERN1ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL23491603 | 0.77 | ALDH1A1 (0.36) | ERN1ALDH1A1KDM4ETSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0334289-B1 | HETEROCYCLIC SUBSTITUTED 5,7-DIHYDROPYRROLO (3,2-F) BENZOXAZOL-6-ONES, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING SAME | Roche Diagnostics GmbH (DE) | 1993-06-16 | — | — | EP | disclosed |
| US-5057526-A | Immunological disorders, suppress organ rejection | BOEHRINGER MANNHEIM GMBH (DE) | 1991-10-15 | — | — | US | disclosed |
| EP-0334289-A1 | Heterocyclic substituted 5,7-dihydropyrrolo (3,2-f) benzoxazol-6-ones, process for their preparation and drugs containing same | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |