SCHEMBL9559840

SCHEMBL9559840

CCOc1ccc([Si](C)(C)CCl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.56
TSHR P16473 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
LTA4H P09960 2/20 0.44
KDM4E B2RXH2 7/20 0.42
SMN1; SMN2 Q16637 5/20 0.42
ALDH1A1 P00352 5/20 0.42
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
HPGD P15428 2/20 0.42
TP53 P04637 1/20 0.42
KMT2A Q03164 3/20 0.41
HSD17B10 Q99714 2/20 0.41
NFKB1 P19838 1/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6054902 0.81 FYN (0.33) NQO1KMT2AMEN1
SCHEMBL10341723 0.80 NQO1 (0.56) NQO1TSHRTDP1LTA4HKDM4E
SCHEMBL3625601 0.79 NQO1 (0.61) NQO1TSHRTDP1LTA4HKDM4E
SCHEMBL7522755 0.79 CA1 (0.48) TDP1KDM4ESMN1; SMN2ALDH1A1NPC1
SCHEMBL8618122 0.79 NQO1 (0.61) NQO1TSHRTDP1LTA4HKDM4E
SCHEMBL9559545 0.79 NQO1 (0.41) NQO1TSHRTDP1LTA4HKDM4E
SCHEMBL9559556 0.79 NQO1 (0.41) NQO1TSHRTDP1KDM4ESMN1; SMN2
SCHEMBL6277365 0.79 NQO1 (0.67) NQO1TSHRTDP1LTA4HKDM4E
SCHEMBL9559676 0.78 TDP1 (0.41) NQO1TSHRTDP1KDM4ESMN1; SMN2
SCHEMBL9559562 0.78 TDP1 (0.41) NQO1TSHRTDP1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5235061-A 2,4-disilaalkanes; agriculture KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1993-08-10 US disclosed
EP-0202893-B1 PESTICIDAL SILYLMETHYL ETHER COMPOUNDS SHIONOGI & CO., LTD. (JP) 1990-01-03 EP disclosed
US-4883789-A Substituted phenyltrialkylsilane insecticides FMC CORPORATION (US) 1989-11-28 US disclosed
US-4804653-A INSECTICIDES, MITICIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 1989-02-14 US disclosed
US-4709068-A NONTOXIC TO FISH FMC CORPORATION (US) 1987-11-24 US disclosed
US-4663314-A PESTICIDES SHIONOGI & CO., LTD. (JP) 1987-05-05 US disclosed
EP-0202893-A2 Pesticidal silylmethyl ether compounds SHIONOGI & CO., LTD. (JP) 1986-11-26 EP disclosed